EQOQ is a patented innovation that restores oocyte and embryo health at the cellular level, empowering women with healthier pregnancies and brighter fertility outcomes.
Restore oocyte quality, renew hope.
Restoring cellular health is the first step to motherhood.
*Names in the success stories have been changed to protect patient privacy. Outcomes and experiences are genuine.
Problem
Conception Challenges, Explained
SIRT1 & Nrf2 downregulation drives ovarian aging
Age-Related Decline
SIRT1 and Nrf2 expression decreases with age, accelerating ovarian aging and reducing oocyte quality. This decline disrupts folliculogenesis by promoting granulosa cell apoptosis, ultimately impairing gamete quality and lowering overall fertility potential.
Obesity, thyroid, and diabetes worsen SIRT1 & Nrf2 loss.
Impact of Comorbidities
Obesity, thyroid disorders, and diabetes suppress SIRT1 and Nrf2 in reproductive tissues, causing oxidative stress and inflammation. This disrupts folliculogenesis and hormonal balance, leading to poor oocyte quality and fertility. Addressing these issues is vital for reproductive health.
Low SIRT1 & Nrf2 causes imbalance and depletion.
SIRT1 in DOR, REPL & PCOS
In DOR, REPL, and PCOS, low SIRT1 & Nrf2 activity worsens hormonal imbalances and follicular depletion, leading to lower oocyte competence and poorer outcomes. Optimal SIRT1 & Nrf2 function is crucial for enhancing fertility.
Age & Fertility
The Impact of Age on Fertility
Shortened telomeres reduce oocyte and embryo quality, causing miscarriages, lower pregnancy rates, and growth restrictions. These effects accompany diminished ovarian reserve markers like AFC and AMH.
Ovarian stimulation and GnRH protocols can worsen fertility by accelerating telomere shortening. SIRT1 & Nrf2 helps mitigate this by enhancing telomerase activity and promoting DNA repair, maintaining oocyte integrity and reducing genetic mutations.
Mitochondrial ROS accumulation exacerbates telomerase dysfunction, causing DNA damage and meiotic arrest. This results in embryonic fragmentation, blastocyst failure, and recurrent pregnancy loss.
Key Biological Regulators
The Molecular Guardians of Oocytes
SIRT1 improves DNA quality in oocytes and maintains spindle structure, preserving normal chromosomal integrity. It enhances telomere integrity and oocyte quality, while decreasing apoptosis and supporting trophoblast function critical for healthy embryogenesis.
Nrf2 activates the antioxidant response element (ARE) and reduces inflammatory markers. By decreasing spindle formation errors and lowering the chances of miscarriage, Nrf2 increases the number of mature follicles and supports reproductive success.
Together, SIRT1 and Nrf2 repair DNA damage in oocytes, maintain spindle and chromosome structure, and elevate the antioxidant response. This combination reduces embryo toxicity, maintains endometrial health, and enhances the chances of successful embryo implantation.
The synergy of SIRT1 and NRF2, supported by Nicotinamide mononucleotide(NMN) and L-ergothioneine, improves blastocyst formation by 48%. This effect is achieved by restoring mitochondrial membrane potential and maintaining genomic stability, effectively counteracting cellular senescence and enhancing reproductive outcomes.
Solution
Our Featured Solution & Its Benefits
EQOQ is a patented SIRT1 and NRF2 activator with Nicotinamide Mononucleotide (250mg) and L-Ergothioneine (0.5mg). It supports telomere integrity, mitochondrial function, and oocyte quality, enhancing reproductive wellness.
Pure Innovation
EQOQ is patented in the US and India, backed by advanced cellular science.
Maintains telomere integrity and safeguards chromosomal stability.
Boosts oocyte quality, supports endometrial health, enhances implantation.
Indications & Recommended Dosage
Women 30+ or with fertility risks
Indications
Above 30 years of age
Diagnosed with PCOS
Women with diminished ovarian reserve
Women with low AMH levels
With co-morbid conditions such as obesity, diabetes, or thyroid disorders
Women with a history of miscarriage or poor obstetric outcomes
1 tablet twice daily (BID), before or during any stimulation protocol, continued until fetal heart sound is detected.
Clinical Experience
Evidence & Recognition
01
US & India patents for innovative fertility therapy
02
Winner of International Best Research Award
03
Supported by clinical data on improved live birth outcomes
Clinical Trial
The FERTSIRT TRIAL
Multicentre, double-blind trial assessing a patented product with SIRT1 and NRF2 activators added to fertility protocols on oocyte quality, embryo grade, and pregnancy outcomes in older women.
Science Simplified
The Role of Telomeres in Fertility
Your fertility clock is ticking at the DNA level.
Telomere erosion triggers chromosomal instability and oocyte senescence. As these protective DNA caps shorten with age, the risk of aneuploidy, spindle failure, and reproductive decline increases.
01
Downregulation of TERT accelerates chromosomal fusion and genomic instability. Shortened telomeres lead to fertilization failure and a cascade of miscarriages.
02
Oxidative stress compounds telomerase dysfunction, triggering germ cell apoptosis at the meiotic checkpoint. The result, embryonic fragmentation and blastocyst failure.
03
Hyperandrogenism disrupts TERT expression; insulin resistance accelerates telomere shortening, leading to chromosomal aging and follicular destruction in PCOS.
EQOQ in DOR/Low AMH
Diminished Ovarian Reserve (DOR)
DOR is marked by fewer ovarian follicles, impaired follicular growth, and reduced oocyte quality, often presenting with low AMH, high FSH, and poor antral follicle counts, leading to lower fertility potential.
How EQOQ Helps
EQOQ enhances fertility in women with DOR by improving oocyte quality and ovarian function. NMN activates sirtuins to restore mitochondrial health, regulate follicle development, and repair DNA, while L-ergothioneine reduces oxidative stress and protects oocytes.
NMN regulates autophagy and stabilizes granulosa cells. L-ergothioneine offers oxidative protection, supporting healthier follicle maturation and reducing loss.
NMN restores mitochondrial function for energy-demanding meiotic processes, while L-ergothioneine prevents oxidative oocyte defects. This enhances mature, normal oocytes for successful fertilization and embryo development.
Ovarian Reserve
NMN sustains NAD+ levels and sirtuin activity critical for follicular survival, while reduced oxidative stress from L-ergothioneine may decrease premature follicle depletion, together helping preserve ovarian reserve.
EQOQ in PCOS and Oocyte Quality
In PCOS, apoptosis in granulosa cells impairs estradiol synthesis. This disrupts follicular development and causes ovulation issues, contributing to reproductive challenges.
EQOQ supports granulosa cell survival, mitochondrial function, estradiol secretion, and gap junction communication for ovarian function.
EQOQ boosts NAD⁺ in the ovaries, enhancing mitochondrial function and energy. It reduces spindle abnormalities and improves oocyte quality, supporting fertility.
Enhancing Fertility in RPL and BOH with EQOQ
Bad Obstetric History (BOH)
BOH refers to previous reproductive challenges such as miscarriages, stillbirths, or premature births, often linked to impaired cellular health and oxidative stress in the uterus.
How EQOQ Helps
EQOQ aids women with BOH by restoring balance and protecting the maternal-fetal interface. NMN boosts DNA repair and oxidative balance, while L-ergothioneine reduces damage and inflammation, enhancing oocyte quality and lowering miscarriage risk.
Endometrial receptivity is essential for successful implantation, but low SIRT1 levels can disrupt decidualization by impairing oxidative balance.
EQOQ’s Role in Fertility
EQOQ enhances endometrial health by activating sirtuins with NMN, boosting repair, reducing inflammation, and promoting decidualization. L-ergothioneine protects cells from oxidative stress, fostering an optimal environment for embryo attachment and growth.
About EQOQ
Science Translated into Clinical Outcomes
01
SIRT1 & NRF2 Upregulation
EQOQ boosts NAD+, activating SIRT1 for histone deacetylation and mitochondrial biogenesis, counteracting oocyte senescence.
02
Telomere Integrity Maintenance
Ergothioneine activates EQOQ, enhancing protective enzymes. This lowers DNA damage and preserves telomere integrity in aging oocytes.
03
Chromosomal Integrity Restoration
Upregulation of SIRT1 extends telomeres and reinforces chromosome stability, reducing nondisjunction errors that
can lead to pregnancy
failure.
04
Embryogenesis
Optimization
Enhanced mitochondrial respiration and ATP supply support spindle formation, leading to better blastocyst rates and reproductive outcomes.
Advanced fertility insights
at your fingertips
EQOQ is changing thousands of lives
Real people to real data to personalized impact of SIRT1 and Nrf2 in Fertility.
Obstetrician & Gynecologist, IVF, GIFT and ICSI Specialist
Infertility & IVF Specialist
MD, DGO, Diploma in Endoscopy (Germany), Specialized training in IVF (Singapore)
Backed by global experts in reproductive medicine
Before EQOQ,
fertility challenges left women without real answers.
Real struggles. Real science-backed hope.
Your patients deserve better outcomes.
Science that helps you see what conventional approaches miss.
